OVERRIDING FUS AUTOREGULATION IN MICE TRIGGERS GAIN-OF-TOXIC DYSFUNCTIONS IN RNA METABOLISM AND AUTOPHAGY-LYSOSOME AXIS

Overriding FUS autoregulation in mice triggers gain-of-toxic dysfunctions in RNA metabolism and autophagy-lysosome axis

Mutations in coding and non-coding regions of FUS cause amyotrophic lateral sclerosis (ALS).The latter mutations may exert toxicity by increasing FUS accumulation.We show here that broad expression within the nervous system of wild-type or either of two ALS-linked mutants of human FUS in mice Linear Actuator produces progressive motor phenotypes ac

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Pilbara rock art: laser scanning, photogrammetry and 3D photographic reconstruction as heritage management tools

Abstract Recording techniques such as laser scanning, photogrammetry and photographic reconstruction are not new to archaeology.However as technology evolves and becomes more Linear Actuator readily available such methods are being more regularly employed within a cultural heritage management context, often by people with little experience in using

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What Is the Most Beautiful Facial Proportion in the 21st Century? Comparative Study among Miss Universe, Miss Universe Thailand, Neoclassical Canons, and Facial Golden Ratios

Background:.An ideal facial proportion has been attempted since the ancient times.However, modern facial proportions of the most beautiful women in the 21st century are unavailable and have never been determined.Methods:.A retrospective review of the photographs of Miss Universe Thailand and Miss Universe from 2001 to 2015 was conducted.All photogr

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Effect of electronic excitations on hydrogen behavior in tungsten

The interaction between ions should be greatly modified under electronic excitation states, subsequently altering the interactions between materials.We perform a series of first-principles calculations to predict the solution and diffusion behaviors of interstitial hydrogen (H) in tungsten (W) under various electronic Sealed Bearing excitations.Qua

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